References
The following is a selection of recently published research papers and studies related to histamine intolerance. Many are open access, meaning that they can be read in full online at no cost. This list is by no means complete, but we hope that it is helpful for you. If you would like to recommend a paper to be listed here, please contact us.
Histamine Intolerance
Overviews & Summaries
Histamine intolerance: The current state of the art
Comas-Basté, Oriol, Sònia Sánchez-Pérez, Maria Teresa Veciana-Nogués, Mariluz Latorre-Moratalla, and María del Carmen Vidal-Carou. “Histamine Intolerance: The Current State of the Art.” Biomolecules 10, no. 8 (August 14, 2020). https://doi.org/10.3390/biom10081181 Open Access
Evaluation of Symptoms and Symptom Combinations in Histamine Intolerance
Schnedl, Wolfgang J., Sonja Lackner, Dietmar Enko, Michael Schenk, Sandra J. Holasek, and Harald Mangge. “Evaluation of Symptoms and Symptom Combinations in Histamine Intolerance.” Intestinal Research 17, no. 3 (July 2019): 427–33. https://doi.org/10.5217/ir.2018.00152 Open Access
Mast Cell Activation
Overviews & Summaries
Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome
Valent, Peter, Cem Akin, Patrizia Bonadonna, Karin Hartmann, Knut Brockow, Marek Niedoszytko, Boguslaw Nedoszytko, et al. “Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome.” The Journal of Allergy and Clinical Immunology: In Practice 7, no. 4 (April 1, 2019): 1125-1133.e1. https://doi.org/10.1016/j.jaip.2019.01.006. Open Access
Recent Advances in Our Understanding of Mast Cell Activation – or Should It Be Mast Cell Mediator Disorders?
Theoharides, Theoharis C., Irene Tsilioni, and Huali Ren. “Recent Advances in Our Understanding of Mast Cell Activation – or Should It Be Mast Cell Mediator Disorders?” Expert Review of Clinical Immunology 15, no. 6 (June 3, 2019): 639–56. https://doi.org/10.1080/1744666X.2019.1596800. Open Access
Mast cell activation may explain many cases of chemical intolerance
Claudia S. Miller, Raymond F. Palmer, Tania T. Dempsey, Nicholas A. Ashford & Lawrence B. Afrin
Environmental Sciences Europe volume 33, Article number: 129 (2021) 17 November 2021
https://doi.org/10.1186/s12302-021-00570-3 Open Access
Mast Cell Responses to Viruses and Pathogen Products
Marshall JS, Portales-Cervantes L, Leong E. Int J Mol Sci. 2019 Aug 30;20(17):4241. doi: 10.3390/ijms20174241. PMID: 31480219; PMCID: PMC6747121. Open Access
Systems, Symptoms & Conditions
Respiratory
The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study
Vassilopoulou, Emilia, George N. Konstantinou, Anastasia Dimitriou, Yannis Manios, Lemonica Koumbi, and Nikolaos G. Papadopoulos. “The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study.” Nutrients 12, no. 11 (November 2020): 3402. https://doi.org/10.3390/nu12113402. Open Access
The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy
Yamauchi, Kohei, and Masahito Ogasawara. “The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy.” International Journal of Molecular Sciences 20, no. 7 (January 2019): 1733. https://doi.org/10.3390/ijms20071733. Open Access
Gastrointestinal
Considering Histamine in Functional Gastrointestinal Disorders
Schnedl, Wolfgang J., and Dietmar Enko. “Considering Histamine in Functional Gastrointestinal Disorders.” Critical Reviews in Food Science and Nutrition 0, no. 0 (July 9, 2020): 1–8. https://doi.org/10.1080/10408398.2020.1791049.
Non-Responsive Celiac Disease May Coincide with Additional Food Intolerance/Malabsorption, Including Histamine Intolerance
Schnedl, Wolfgang J., Harald Mangge, Michael Schenk, and Dietmar Enko. “Non-Responsive Celiac Disease May Coincide with Additional Food Intolerance/Malabsorption, Including Histamine Intolerance.” Medical Hypotheses, November 21, 2020, 110404. https://doi.org/10.1016/j.mehy.2020.110404.
Migraine
Histamine and Migraine Revisited: Mechanisms and Possible Drug Targets
Worm, Jacob, Katrine Falkenberg, and Jes Olesen. “Histamine and Migraine Revisited: Mechanisms and Possible Drug Targets.” The Journal of Headache and Pain 20, no. 1 (March 25, 2019). https://doi.org/10.1186/s10194-019-0984-1 Open Access
Migraines Appear More Likely to Be Caused by Histamine Rather than Ethanol
Schnedl, Wolfgang, and Robert Queissner. “Migraines Appear More Likely to Be Caused by Histamine Rather than Ethanol.” European Journal of Neurology 26 (May 20, 2019). https://doi.org/10.1111/ene.14003.
Neurological & Psychiatric
Mast Cell Activation Disease: An Underappreciated Cause of Neurologic and Psychiatric Symptoms and Diseases
Afrin, Lawrence B., Dieter Pöhlau, Martin Raithel, Britta Haenisch, Franz L. Dumoulin, Juergen Homann, Uwe M. Mauer, Sabrina Harzer, and Gerhard J. Molderings. “Mast Cell Activation Disease: An Underappreciated Cause of Neurologic and Psychiatric Symptoms and Diseases.” Brain, Behavior, and Immunity 50 (November 1, 2015): 314–21. https://pubmed.ncbi.nlm.nih.gov/26162709/
Diet & Nutrient Therapy
Low histamine diet
Histamine-Reduced Diet and Increase of Serum Diamine Oxidase Correlating to Diet Compliance in Histamine Intolerance
Lackner, Sonja, Verena Malcher, Dietmar Enko, Harald Mangge, Sandra J. Holasek, and Wolfgang J. Schnedl. “Histamine-Reduced Diet and Increase of Serum Diamine Oxidase Correlating to Diet Compliance in Histamine Intolerance.” European Journal of Clinical Nutrition 73, no. 1 (January 2019): 102–4. https://doi.org/10.1038/s41430-018-0260-5.
A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria
Son, Jee Hee, Bo Young Chung, Hye One Kim, and Chun Wook Park. “A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria.” Annals of Dermatology 30, no. 2 (April 2018): 164–72. https://doi.org/10.5021/ad.2018.30.2.164. Open Access
DAO supplementation
Diamine Oxidase Supplementation Improves Symptoms in Patients with Histamine Intolerance
Schnedl, Wolfgang J., Michael Schenk, Sonja Lackner, Dietmar Enko, Harald Mangge, and Florian Forster. “Diamine Oxidase Supplementation Improves Symptoms in Patients with Histamine Intolerance.” Food Science and Biotechnology 28, no. 6 (December 1, 2019): 1779–84. https://doi.org/10.1007/s10068-019-00627-3 Open Access
Diamine Oxidase (DAO) Supplement Reduces Headache in Episodic Migraine Patients with DAO Deficiency: A Randomized Double-Blind Trial
Izquierdo-Casas, Joan, Oriol Comas-Basté, M. Luz Latorre-Moratalla, Marian Lorente-Gascón, Adriana Duelo, Luis Soler-Singla, and M. Carmen Vidal-Carou. “Diamine Oxidase (DAO) Supplement Reduces Headache in Episodic Migraine Patients with DAO Deficiency: A Randomized Double-Blind Trial.” Clinical Nutrition 38, no. 1 (February 1, 2019): 152–58. https://doi.org/10.1016/j.clnu.2018.01.013.
Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study
Yacoub, Mona-Rita, Giuseppe A. Ramirez, Alvise Berti, Giuseppe Mercurio, Daniela Breda, Nicoletta Saporiti, Samuele Burastero, Lorenzo Dagna, and Giselda Colombo. “Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study.” International Archives of Allergy and Immunology 176, no. 3–4 (2018): 268–71. https://doi.org/10.1159/000488142.
Natural mast cell stabilizers
Impact of Polyphenols on Mast Cells with Special Emphasis on the Effect of Quercetin and Luteolin.
Shaik, Yasdani, Alessandro Caraffa, Gianpaolo Ronconi, Gianfranco Lessiani, and Pio Conti. “Impact of Polyphenols on Mast Cells with Special Emphasis on the Effect of Quercetin and Luteolin.” Central-European Journal of Immunology 43, no. 4 (2018): 476–81. https://doi.org/10.5114/ceji.2018.81347. Open Access