References

The following is a selection of recently published research papers and studies related to histamine intolerance. Many are open access, meaning that they can be read in full online at no cost. This list is by no means complete, but we hope that it is helpful for you. If you would like to recommend a paper to be listed here, please contact us

Histamine Intolerance

Overviews & Summaries

Histamine intolerance: The current state of the art 
Comas-Basté, Oriol, Sònia Sánchez-Pérez, Maria Teresa Veciana-Nogués, Mariluz Latorre-Moratalla, and María del Carmen Vidal-Carou. “Histamine Intolerance: The Current State of the Art.” Biomolecules 10, no. 8 (August 14, 2020). https://doi.org/10.3390/biom10081181 
Open Access

Evaluation of Symptoms and Symptom Combinations in Histamine Intolerance

Schnedl, Wolfgang J., Sonja Lackner, Dietmar Enko, Michael Schenk, Sandra J. Holasek, and Harald Mangge. “Evaluation of Symptoms and Symptom Combinations in Histamine Intolerance.” Intestinal Research 17, no. 3 (July 2019): 427–33. https://doi.org/10.5217/ir.2018.00152  Open Access

Mast Cell Activation

Overviews & Summaries

Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome

Valent, Peter, Cem Akin, Patrizia Bonadonna, Karin Hartmann, Knut Brockow, Marek Niedoszytko, Boguslaw Nedoszytko, et al. “Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome.” The Journal of Allergy and Clinical Immunology: In Practice 7, no. 4 (April 1, 2019): 1125-1133.e1. https://doi.org/10.1016/j.jaip.2019.01.006Open Access

Recent Advances in Our Understanding of Mast Cell Activation – or Should It Be Mast Cell Mediator Disorders?

Theoharides, Theoharis C., Irene Tsilioni, and Huali Ren. “Recent Advances in Our Understanding of Mast Cell Activation – or Should It Be Mast Cell Mediator Disorders?” Expert Review of Clinical Immunology 15, no. 6 (June 3, 2019): 639–56. https://doi.org/10.1080/1744666X.2019.1596800Open Access

Systems, Symptoms & Conditions

Respiratory

The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study

Vassilopoulou, Emilia, George N. Konstantinou, Anastasia Dimitriou, Yannis Manios, Lemonica Koumbi, and Nikolaos G. Papadopoulos. “The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study.” Nutrients 12, no. 11 (November 2020): 3402. https://doi.org/10.3390/nu12113402Open Access

The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

Yamauchi, Kohei, and Masahito Ogasawara. “The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy.” International Journal of Molecular Sciences 20, no. 7 (January 2019): 1733. https://doi.org/10.3390/ijms20071733Open Access

Gastrointestinal 

Considering Histamine in Functional Gastrointestinal Disorders

Schnedl, Wolfgang J., and Dietmar Enko. “Considering Histamine in Functional Gastrointestinal Disorders.” Critical Reviews in Food Science and Nutrition 0, no. 0 (July 9, 2020): 1–8. https://doi.org/10.1080/10408398.2020.1791049.

Non-Responsive Celiac Disease May Coincide with Additional Food Intolerance/Malabsorption, Including Histamine Intolerance

Schnedl, Wolfgang J., Harald Mangge, Michael Schenk, and Dietmar Enko. “Non-Responsive Celiac Disease May Coincide with Additional Food Intolerance/Malabsorption, Including Histamine Intolerance.” Medical Hypotheses, November 21, 2020, 110404. https://doi.org/10.1016/j.mehy.2020.110404.

Migraine

Histamine and Migraine Revisited: Mechanisms and Possible Drug Targets

Worm, Jacob, Katrine Falkenberg, and Jes Olesen. “Histamine and Migraine Revisited: Mechanisms and Possible Drug Targets.” The Journal of Headache and Pain 20, no. 1 (March 25, 2019). https://doi.org/10.1186/s10194-019-0984-1.  Open Access

Migraines Appear More Likely to Be Caused by Histamine Rather than Ethanol

Schnedl, Wolfgang, and Robert Queissner. “Migraines Appear More Likely to Be Caused by Histamine Rather than Ethanol.” European Journal of Neurology 26 (May 20, 2019). https://doi.org/10.1111/ene.14003.

Neurological & Psychiatric

Mast Cell Activation Disease: An Underappreciated Cause of Neurologic and Psychiatric Symptoms and Diseases

Afrin, Lawrence B., Dieter Pöhlau, Martin Raithel, Britta Haenisch, Franz L. Dumoulin, Juergen Homann, Uwe M. Mauer, Sabrina Harzer, and Gerhard J. Molderings. “Mast Cell Activation Disease: An Underappreciated Cause of Neurologic and Psychiatric Symptoms and Diseases.” Brain, Behavior, and Immunity 50 (November 1, 2015): 314–21. https://doi.org/10.1016/j.bbi.2015.07.002.

Diet & Nutrient Therapy

Low histamine diet 

Histamine-Reduced Diet and Increase of Serum Diamine Oxidase Correlating to Diet Compliance in Histamine Intolerance

Lackner, Sonja, Verena Malcher, Dietmar Enko, Harald Mangge, Sandra J. Holasek, and Wolfgang J. Schnedl. “Histamine-Reduced Diet and Increase of Serum Diamine Oxidase Correlating to Diet Compliance in Histamine Intolerance.” European Journal of Clinical Nutrition 73, no. 1 (January 2019): 102–4. https://doi.org/10.1038/s41430-018-0260-5.

A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria

Son, Jee Hee, Bo Young Chung, Hye One Kim, and Chun Wook Park. “A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria.” Annals of Dermatology 30, no. 2 (April 2018): 164–72. https://doi.org/10.5021/ad.2018.30.2.164Open Access

DAO supplementation

Diamine Oxidase Supplementation Improves Symptoms in Patients with Histamine Intolerance

Schnedl, Wolfgang J., Michael Schenk, Sonja Lackner, Dietmar Enko, Harald Mangge, and Florian Forster. “Diamine Oxidase Supplementation Improves Symptoms in Patients with Histamine Intolerance.” Food Science and Biotechnology 28, no. 6 (December 1, 2019): 1779–84. https://doi.org/10.1007/s10068-019-00627-3   Open Access

Diamine Oxidase (DAO) Supplement Reduces Headache in Episodic Migraine Patients with DAO Deficiency: A Randomized Double-Blind Trial

Izquierdo-Casas, Joan, Oriol Comas-Basté, M. Luz Latorre-Moratalla, Marian Lorente-Gascón, Adriana Duelo, Luis Soler-Singla, and M. Carmen Vidal-Carou. “Diamine Oxidase (DAO) Supplement Reduces Headache in Episodic Migraine Patients with DAO Deficiency: A Randomized Double-Blind Trial.” Clinical Nutrition 38, no. 1 (February 1, 2019): 152–58. https://doi.org/10.1016/j.clnu.2018.01.013.

Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study

Yacoub, Mona-Rita, Giuseppe A. Ramirez, Alvise Berti, Giuseppe Mercurio, Daniela Breda, Nicoletta Saporiti, Samuele Burastero, Lorenzo Dagna, and Giselda Colombo. “Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study.” International Archives of Allergy and Immunology 176, no. 3–4 (2018): 268–71. https://doi.org/10.1159/000488142.

Natural mast cell stabilizers 

Impact of Polyphenols on Mast Cells with Special Emphasis on the Effect of Quercetin and Luteolin.

Shaik, Yasdani, Alessandro Caraffa, Gianpaolo Ronconi, Gianfranco Lessiani, and Pio Conti. “Impact of Polyphenols on Mast Cells with Special Emphasis on the Effect of Quercetin and Luteolin.” Central-European Journal of Immunology 43, no. 4 (2018): 476–81. https://doi.org/10.5114/ceji.2018.81347.   Open Access

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